It is possible to experience every quest in a single playthrough; however, if you want to see every single piece of content in the game, it will require multiple playthroughs.  Much like the Fallout and Mass Effect games, quests can be resolved in different ways, and different “character builds” receive access to different lines of dialogue in certain places.

If you truly want to experience all that Puzzleburg has to offer, then that will take at least five different playthroughs, one for each of the following character classes: dance choreographer, NASA engineer, cookbook author, author of detective novels, and biographer.

Along the way, you can read through one of three different books, and you can mix and match these choices to create your own backstory - perhaps you are a biographer who wants to read a biography to keep up with what your colleagues are publishing or perhaps you’re an engineer who reads biographies for fun.

You can create many different backstories with all of the choices in the game, but to see all the content requires a minimum of five playthroughs if you really want to see everything.